EVALUATION OF THE SEMICARBAZONES, THIOSEMICARBAZONES AND BIS-CARBOHYDRAZONES OF SOME ARYL ALICYCLIC KETONES FOR ANTICONVULSANT AND OTHER BIOLOGICAL PROPERTIES

A number of aryl alicyclic ketones were converted to their correspondi ng semicarbazones, thiosemicarbazones and bis-carbohydrazones. Anticon vulsant activity was displayed by most of the compounds in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screen s when given intraperitoneally to mice. However, on oral administratio n to rats, a marked selective activity in the MES screen only was note d. X-ray crystallography on five semicarbazones was undertaken in orde r to find correlations between the shapes of these molecules and antic onvulsant properties. The thiosemicarbazones displayed greater cytotox icity to P388D1 and L1210 cells than the semicarbazones while a number of human tumors and different viruses were, in general, insensitive t o representative compounds.