SYNTHESIS OF DL-CIS- AND NYL)-AMINOMETHYL-1,3-DIOXOLAN-5-YL]-5(Z)-HEPTENOIC ACID ANALOGS AS PLATELET THROMBOXANE A(2) RECEPTOR ANTAGONISTS

The title compounds have been synthesized and their in vitro thromboxa ne A(2) (TxA(2)) receptor antagonist activity evaluated. Both cis and trans isomers (1, 2) were shown to specifically inhibit submaximal hum an platelet aggregation induced by 225 nM U46619 in a dose-dependent m anner with an IC50 of 1 mu M. The concentration of 1 and 2 required to completely block maximal aggregation induced by 3 mu M U46619 was 3 m u(M).