SYNTHESIS OF NOVEL INHIBITORS OF ELECTRON-TRANSPORT

Authors
COCKERILL GS LEVETT PC WHITING DA
Citation
Gs. Cockerill et al., SYNTHESIS OF NOVEL INHIBITORS OF ELECTRON-TRANSPORT, Journal of the Chemical Society. Perkin transactions. I, (9), 1995, pp. 1103-1113
Citations number
44
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
9
Year of publication
1995
Pages
1103 - 1113
Database
ISI
SICI code
0300-922X(1995):9<1103:SONIOE>2.0.ZU;2-U
Abstract
Molecular modelling comparisons of several known natural and synthetic inhibitors of electron transport, e.g. rotenone, papaverine, and pier icidin A, suggested new 'hybrid' structures 8-12, and relatives, as po tential new inhibitors. Synthetic routes to these targets, some of whi ch display significant biological activity, are outlined.