OBJECTIVE: To characterize risk factors for outbreak-associated influe
nza illness and death in a nursing home. DESIGN: Outbreak investigatio
n with predetermined and concurrently determined risk information. SET
TING: A nursing home service in a multiward chronic care hospital, Hon
olulu, Oahu, 1989 to 1990. PATIENTS: Elderly nursing home patients rec
eiving long-term care. INTERVENTIONS: Influenza vaccination, amantadin
e administration, and infection control measures. RESULTS: Neither rou
tine infection control measures nor vaccination prevented illness, com
plications, or death in a nursing home outbreak of influenza A. The 55
% case-fatality rate resulted from severe pneumonia. influenza transmi
ssion may have been mediated by staff via either contaminated hands or
fomites. CONCLUSIONS: Data from this and other outbreaks suggest that
recommendations for preventing nosocomial influenza in the nation's 1
.5 million nursing home residents should be reconsidered.