DIORGANOSILICON(IV) COMPLEXES OF FLUORO-IMINES - SYNTHETIC, SPECTROSCOPIC AND BIOLOGICAL ASPECTS

The synthetic, spectroscopic and biological studies of some diorganosi licon(IV) complexes derived from fluoroimines having NS and NO donor s ystems have been undertaken. The fluoroimines were prepared by the con densation of 2-Fluorobenzaldehyde and 1-(2-Fluorophenyl)-ethanone with hydrazinecarbothioamide and hydrazinecarboxamide. These imines, on in teraction with diorganosilicon(IV) chlorides, yield complexes having S i-S/Si-O and Si<--N bonds. The structures of these compounds have been elucidated by microestimations and spectral [(UV), (IR), (proton-1, c arbon-13, fluorine-19 and silicon-29 NMR)] studies which unerringly po int to a trigonal bipyramidal and octahedral geometries for unimolar a nd bimolar reactions, respectively, around silicon(IV), as the active lone pair of nitrogen is also included in the coordination sphere. Stu dies were conducted to assess the comparative growth inhibiting potent ial of the synthesized complexes against the fluoroimines for a variet y of fungal and bacterial strains. The studies demonstrate that the co ncentrations reached levels which are sufficient to inhibit and kill t he pathogens. The results of biological studies have also been compare d with the conventional standards, Bavistin and Streptomycin, taken fo r antifungal and antibacterial activities, respectively.