ENANTIOMERIC RESOLUTION OF CHIRAL IMIDAZOLE DERIVATIVES USING CAPILLARY ELECTROPHORESIS WITH CYCLODEXTRIN-TYPE BUFFER MODIFIERS

Enantiomeric resolutions of some chiral pharmaceuticals containing the imidazole (1,3-diazole) moiety were carried out using capillary elect rophoresis. Various native cyclodextrins (alpha-, beta- and gamma-cycl odextrin) and derivatized cydodextrins (hydroxypropyl-, and sulfobutyl ether-beta-cyclodextrin) were used as chiral buffer modifiers. The ef fects of the cavity size, the structure and the charge of the selector s on the chiral recognition ability were evaluated. The influence of t he type and concentration of the organic modifier on the separation of miconazole enantiomers and the pH of the run buffer on the separation of enilconazole enantiomers was also studied.