COMPLETE DESIGN OF A SIMULATED MOVING-BED

The operating conditions of a simulated moving bed working under condi tions of non-linear chromatography are difficult to find experimentall y. A design procedure based on the modelling of multi-component chroma tography is described. This rigorous and general procedure can be appl ied provided that basic data characterizing the experimental system ar e available. Even if the main parameters to be set are the flow-rates (one internal flow-rate and three out of four inlet/outlet flow-rates) , it is explained how other free working parameters can be chosen. Spe cial attention is paid to the column length, mobile phase velocity and particle size. It is shown how strongly they can influence the perfor mance of a simulated moving bed.