SEPARATION OF ENANTIOMERS OF ,2,7,7A-TETRAHYDRO-3-METHOXYNAPHTHA-(2,3B)-OXIRANE BY LIQUID-CHROMATOGRAPHY - LABORATORY-SCALE ELUTION CHROMATOGRAPHY AND MODELING OF SIMULATED MOVING-BED

The separation of enantiomers of ,2,7,7a-tetrahydro-3-methoxynaphtha-( 2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns wa s investigated on the laboratory scale. The performance of the columns was calculated by HEFT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equil ibrium isotherms were calculated from single isotherms by using the id eal adsorbed solution (IAS) model. Simulation of continuous chromatogr aphic separation of the racemic mixture of Sandoz epoxide in a simulat ed moving bed was carried out and the effect of mass transfer coeffici ent on process performance was analysed.