P. Muller et al., PROTECTIVE EFFECT OF RANITIDINE IN IBUPRO FEN GASTRODUODENOPATHY - ANENDOSCOPICALLY CONTROLLED DOUBLE-BLIND-STUDY IN HEALTHY-VOLUNTEERS, Arzneimittel-Forschung, 45(5), 1995, pp. 601-603
In a randomized parallel double-blind study the gastroduodenal effects
of 600 mg ibuprofen racemate (CAS 15687-27-1) tid in the presence of
150 mg ranitidine (CAS 66357-35-5, Sostril(R)) bid or placebo was eval
uated in 32 healthy volunteers under going upper gastrointestinal endo
scopy. Drugs were taken during a period of 7 days. Endoscopic controls
were performed at entry and repeated after 7 days of treatment. A dam
aging score was used to asses the lesions.