HIGHLY DIASTEREOSELECTIVE ADDITION OF ORGANOMETALLICS TO NOVEL CHIRALALPHA-KETOAMIDES OF (S)-2-METHOXYMETHYLINDOLINE

Authors
KIM YH BYUN IS CHOI JY
Citation
Yh. Kim et al., HIGHLY DIASTEREOSELECTIVE ADDITION OF ORGANOMETALLICS TO NOVEL CHIRALALPHA-KETOAMIDES OF (S)-2-METHOXYMETHYLINDOLINE, Tetrahedron : asymmetry, 6(5), 1995, pp. 1025-1026
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
5
Year of publication
1995
Pages
1025 - 1026
Database
ISI
SICI code
0957-4166(1995)6:5<1025:HDAOOT>2.0.ZU;2-U
Abstract
The stereocontrolled nucleophilic addition of organametallics to novel chiral alpha-ketoamides which were synthesized from (S)-2-methoxymeth ylindoline as a chiral auxiliary was carried out to obtain alpha-hydro xyamides with extremely high diastereoselectivities ( up to dr greater than or equal to 99:1).