A NOVEL NUCLEOSIDE PHOSPHORAMIDITE SYNTHON DERIVED FROM 1R,2S-EPHEDRINE

Authors
IYER RP YU D HO NH TAN WT AGRAWAL S
Citation
Rp. Iyer et al., A NOVEL NUCLEOSIDE PHOSPHORAMIDITE SYNTHON DERIVED FROM 1R,2S-EPHEDRINE, Tetrahedron : asymmetry, 6(5), 1995, pp. 1051-1054
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
5
Year of publication
1995
Pages
1051 - 1054
Database
ISI
SICI code
0957-4166(1995)6:5<1051:ANNPSD>2.0.ZU;2-U
Abstract
The stereoselective synthesis of the nucleoside phosphoramidite 6 by r eaction of the chiral oxazaphospholidine 4 with 5'-DMT-T is reported. The novel phosphoramidite synthon, 6, is stereoselectively converted t o 8 by oxidative sulfurization with 1. The oxazaphospholidines, 6 and 8, are a new class of potential nucleoside synthons for the synthesis of oligonucleotides.