EFFICIENT PATHWAYS TO (R)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND (S)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND SOME DERIVATIVES

Authors
DANIELMEIER K STECKHAN E
Citation
K. Danielmeier et E. Steckhan, EFFICIENT PATHWAYS TO (R)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND (S)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND SOME DERIVATIVES, Tetrahedron : asymmetry, 6(5), 1995, pp. 1181-1190
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
5
Year of publication
1995
Pages
1181 - 1190
Database
ISI
SICI code
0957-4166(1995)6:5<1181:EPT(A(>2.0.ZU;2-V
Abstract
2-Oxazolidinones are a very interesting class of compounds due to thei r various pharmacological effects. Two new syntheses of enantiomerical ly pure (R)- and (S)-5-hydrolymethyl-2-oxazolidinone have been develop ed starting with D- mannitol, L-ascorbic acid and (R)- or (S)-malic ac id. (R)- and (S)-5-hydroxylmethyl-2-oxazolidinone have been used to sy nthesize some new homochiral 2-oxazolidinone derivatives.