E. Sam et al., APOMORPHINE PHARMACOKINETICS IN PARKINSONISM AFTER INTRANASAL AND SUBCUTANEOUS APPLICATION, European journal of drug metabolism and pharmacokinetics, 20(1), 1995, pp. 27-33
Apomorphine was administered subcutaneously and intranasally to 7 pati
ents suffering from Parkinsonism with 'on-off' problems. This comparat
ive pharmacokinetic study showed that the two routes of administration
are comparable with respect to absorption kinetics. Apomorphine is ra
pidly absorbed when administered intranasally or subcutaneously with a
n absorption half life of 8.6 min and 5.8 min, respectively. The high
rate of absorption is also reflected by the time for the plasma concen
tration to peak (t(max)) and the lag times. The t(max) was 23 min for
intranasal route and 18 min for the subcutaneous route while the lag t
imes were 2.8 min and 3.9 min, respectively. The bioavailability of in
tranasal apomorphine compared to the subcutaneous route amounted to 45
%. After intranasal and subcutaneous administrations, the elimination
half life of apomorphine amounted to 31 min and 27 min, respectively.