EXCRETION STUDY OF FURAZABOL, AN ANABOLIC-STEROID, IN HUMAN URINE

Furazabol and 16-hydroxyfurazabol represented the most abundant peaks in urinary metabolic profiles for two men obtained by gas chromatograp hy-mass spectrometry (GC-MS) after oral administration of 5 mg furazab ol. The excreted amounts of unchanged furazabol were determined and it s response in GC-MS was compared with that of the 16-hydroxy metabolit e. The maximum excretion rates of these compounds were reached 2-3 h a fter oral administration. The half-lives of unchanged furazabol for tw o human subjects, were 1.87 and 1.29 h respectively and the recovered amount in 48 h was 24% (33% for one, 15% for the other). Also the spec trum of an unidentified metabolite is reported.