THE CONTROL OF SEPTUM FORMATION AND CYTOKINESIS IN FISSION YEAST

Our understanding of the control of cytokinesis is limited in comparis on with our knowledge of the controls over the initiation of S phase o r mitosis. Study of genetically tractable systems such as Schizosaccha romyces pombe are a useful way to address this problem, since mutants defective in regulation of cytokinesis have been identified. Cloning a nd analysts of the proteins they encode has begun to shed light upon h ow formation of the division septum is initiated and directed to the c orrect place in the cell. Some of these mutants may also be implicated in coordinating mitosis and responsible cytokinesis.