STRUCTURAL, CONFORMATIONAL AND PHARMACOLOGICAL STUDY OF SOME ESTERS DERIVED FROM YL-2,4-DIPBENYL-3-AZABICYCLO[3.3.1]NONAN-9-BETA-OL

A series of some esters derived from 3-methyl-2,4-diphenyl-3-azabicycl o[3.3.1]nonan-9 beta-ol were synthesized and studied by H-1 and C-13 N MR spectroscopy, and the crystal structure of 3-methyl-2,4-diphenyl-9 (3,5-dimethylbenzoyloxy)-3-azabicyclo[3.3.1]nonane (II) has been deter mined by X-ray diffraction. The compounds studied display, in deuteroc hloroform, a flattened chair-chair conformation with the cyclohexane r ing more flattened than the piperidine moiety and the N-CH3 groups in equatorial position. Pharmacological assays on mices were drawn to eva luate drug-induced behavioral alteration, peripheral or central acute toxicity analgesic and neuroleptic activity.