THYROTROPIN-SECRETING PITUITARY-ADENOMA ASSOCIATED WITH HYPOPITUITARISM AND DIABETES-INSIPIDUS IN AN ADOLESCENT BOY

A 13 year-old boy was referred to our hospital because of several mont hs of school performance deterioration, behavioral changes and seconda ry enuresis. Hyperthyroidism, diabetes insipidus and hypopituitarism d ue to thyrotropin secreting pituitary macroadenoma were found. Six wee ks of therapy with octreotide failed to reduce the serum TSH levels an d the tumor size. Transsphenoidal pituitary surgery had a transient ef fect on serum TSH levels as the patient redeveloped hyperthyroidism wi th elevated serum TSH levels. Several months had elapsed from the time the patient first presented with the symptoms to the time the diagnos is was made. Thyrotropin secreting pituitary adenoma is a rare cause o f hyperthyroidism. Recognizing the signs of the disease might lead to early diagnosis and might improve the prognosis.