SELECTIVE DETERMINATION OF PEPTIDES CONTAINING SPECIFIC AMINO-ACID-RESIDUES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS

HPLC and CE methods for the selective determination of peptides contai ning cysteine, arginine, tryptophan, tyrosine and proline are reviewed . Chemical derivatization combined with UV-visible and fluorescent det ection is the most often used method. The derivatization conditions, s ensitivities, advantages, disadvantages and applications of these meth ods are discussed. Related methods are also considered.