Mtd. Cronin et Jc. Dearden, QSAR IN TOXICOLOGY .2. PREDICTION OF ACUTE MAMMALIAN TOXICITY AND INTERSPECIES CORRELATIONS, Quantitative structure-activity relationships, 14(2), 1995, pp. 117-120
A critical review is given of quantitative structure-activity relation
ships (QSAR) for the prediction of mammalian toxicological endpoints.
QSAR predictions for mammalian toxicity are generally poorly developed
although hydrophobicity correlates well with the toxicity of unreacti
ve chemicals. Interspecies correlations of acute toxicity are discusse
d and when the mode of toxic action is taken into account these may pr
ovide a valuable source of information for comparative toxicity and th
e potential use of surrogate species for testing.