The occurrence of viridans streptococcal bacteraemia (VSB) in a London
postgraduate teaching hospital was analysed retrospectively. Over a 3
0-month period, 39 patients with VSB were identified, and the clinical
significance of VSB was assessed for each, based upon clinical and la
boratory information. Endocarditis accounted for only 13% of the total
patients with apparent VSB. A greater proportion of patients with VSB
originated from the haematology unit (21%) and in particular, the bon
emarrow transplantation unit (15%). VSB also occurred in patients with
solid epithelial malignancies and in children aged <12 months. Mortal
ity associated with VSB was 7%. Viridans streptococci are emerging as
important pathogens in previously unrecognized clinical settings, part
icularly hospitalized, immunocompromised patients.