AQUEOUS-SOLUTIONS OF POLY-N-ALKYL-SUBSTITUTED ACRYLAMIDES - STRUCTUREAND PROPERTIES RELATED TO TARGETED TRANSPORT

Temperature dependence of structure and properties of poly-N-alkyl-sub stituted acrylamides and their aqueous solutions has been studied by I R-Fourier spectroscopy technique. For poly-N-alkyl-substituted acrylam ides showing lower critical solution temperature, a specific H-bonded ring structure involving alkyl amide units of a polymer and hydroxyl f unctions of water was discovered. A new approach to the targeted trans port of physiologically active compounds was proposed. The approach in volves the immobilization of these compounds on activated poly-N-alkyl -substituted acrylamides and heating the delivery site above critical temperature.