SYNTHESIS AND NEMATOCIDAL ACTIVITIES OF NEW ANALOGS OF PYRANTEL

Authors
KRAOUTI N CAUJOLLE R LABIDALLE S PAYARD M LOISEAU PM BORIES C GAYRAL P
Citation
N. Kraouti et al., SYNTHESIS AND NEMATOCIDAL ACTIVITIES OF NEW ANALOGS OF PYRANTEL, European journal of medicinal chemistry, 30(6), 1995, pp. 509-513
Citations number
16
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
6
Year of publication
1995
Pages
509 - 513
Database
ISI
SICI code
0223-5234(1995)30:6<509:SANAON>2.0.ZU;2-T
Abstract
A set of new analogs of pyrantel was synthesized in good yields by lit hiation of 1,2-dimethyltetrahydropyrimidine with n-butyllithium in tet rahydrofuran and condensation with aromatic esters. Spectrometric stud ies showed the large influence of intramolecular bonding in the tautom eric equilibria between the possible structures. Anthelmintic screenin g showed in vitro efficiency against Molinema dessetae, but a weak act ivity against Rhabditis pseudoelongata and Nippostrongylus brasiliensi s.