SYNTHESIS OF N-1-SUBSTITUTED BENZAMIDINES - EFFECTS ON BLOOD-COAGULATION, PLATELET-AGGREGATION AND ANTIARRHYTHMIC ACTIVITY

Authors
FERRONI R SIMONI D MANFREDINI S GUARNERI M ORLANDINI P BARBIERI M FRANZE GP MUGELLI A
Citation
R. Ferroni et al., SYNTHESIS OF N-1-SUBSTITUTED BENZAMIDINES - EFFECTS ON BLOOD-COAGULATION, PLATELET-AGGREGATION AND ANTIARRHYTHMIC ACTIVITY, Arzneimittel-Forschung, 45-1(6), 1995, pp. 665-669
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-1
Issue
6
Year of publication
1995
Pages
665 - 669
Database
ISI
SICI code
0004-4172(1995)45-1:6<665:SONB-E>2.0.ZU;2-E
Abstract
A series of N-1-substituted-4-alkoxybenzamidines was synthesized and t ested in vitro for their inhibitory effects on blood coagulation and a gonist induced platelet aggregation. The antiarrhythmic activity again st chloroform-induced arrhythmias in mice was also evaluated. The biol ogical activity of the title compounds is reported in comparison with that of procainamine; among the new products described, IVi and IVe we re found to have the most potent anti-platelet and antiarrhythmic acti vity, respectively. The structure-activity relationships are discussed .