CARDIOTOXICITY OF PARENTERALLY ADMINISTERED IRON COMPLEXES

Authors
ANGHILERI LJ MAINCENT P THOUVENOT P
Citation
Lj. Anghileri et al., CARDIOTOXICITY OF PARENTERALLY ADMINISTERED IRON COMPLEXES, Arzneimittel-Forschung, 45-1(6), 1995, pp. 679-681
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-1
Issue
6
Year of publication
1995
Pages
679 - 681
Database
ISI
SICI code
0004-4172(1995)45-1:6<679:COPAIC>2.0.ZU;2-B
Abstract
The role of cell calcium overload in the cardiotoxicity of low molecul ar weight iron complexes has been studied using Ca-45(2+)-uptake deter minations in mice intraperitoneally injected with ferric lactate lacta te and ferric-ATP complex. Heart tissue shows a very high increase of Ca-45(2+)-uptake which appears to corroborate the hypothesis of cardio toxicity by calcium overload ATP seems to play a role in the degree of iron complex efficiency as cell calcium homeostasis modifier.