SYNTHESIS AND ANALYTICAL PROFILE OF THE NEW POTENT ANTIBRONCHOSPASTICAGENT 7-[(2,2-DIMETHYL)PROPYL]-1-METHYL XANTHINE

Authors
AGOSTINI O BONACCHI G COPPINI G DIMARCO G PAOLI P TOJA E
Citation
O. Agostini et al., SYNTHESIS AND ANALYTICAL PROFILE OF THE NEW POTENT ANTIBRONCHOSPASTICAGENT 7-[(2,2-DIMETHYL)PROPYL]-1-METHYL XANTHINE, Arzneimittel-Forschung, 45-1(6), 1995, pp. 684-688
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-1
Issue
6
Year of publication
1995
Pages
684 - 688
Database
ISI
SICI code
0004-4172(1995)45-1:6<684:SAAPOT>2.0.ZU;2-Q
Abstract
7-[(2,2-Dimethyl)propyl]-1-methyl xanthine (GAS 155006-67-0, MX2/120) is a new potent antibronchospastic agent with negligible side effects. The synthesis involves the alkylation of 3-benzyl-1-methyl xanthine w ith neopentyl bromide followed by removal of the benzyl protecting gro up Main physico-chemical properties were determined using NMR, MS, IR, UV spectra and X-ray crystal structure. A quantitative determination of substances related to MX2/120 and of residual solvents by means of HPLC and GC: respectively, is described. MX2/120 is safely stored at r oom temperature for a long time.