EFFECTS OF FLAVONOIDS ON PARIETAL-CELL ACID-SECRETION, GASTRIC-MUCOSAL PROSTAGLANDIN PRODUCTION AND HELICOBACTER-PYLORI GROWTH

The effect of the flavonoids flavone, flavanone and quercetin on parie tal cell acid production, H+/K+-ATPase activity, gastric mucosal prost aglandin E(2) biosynthesis and Helicobacter pylori growth was studied. All flavonoids inhibited acid production in isolated parietal cells i n response to histamine and dibutyryl-cAMP stimulation (IC50 values be tween 26 and 139 mu mol/l) and inhibited H+/K+-ATPase activity. Inhibi tion of H+/K+-ATPase activity was dependent on the ATP concentration F luorescence measurements showed that flavanone reacts with ATP. These findings indicate that the inhibitory action of flavonoids on H+/K+-AT Pase activity is related to their ability to complex ATP. Flavone and flavanone (10 and 100 mu mol/l) stimulated prostaglandin E(2) producti on in isolated gastric mucosal cells. Furthermore, the compounds inhib ited Helicobacter pylori growth in a concentration-dependent manner Fr om these Finding it appears that flavonoids are a group of compounds w hich could have a therapeutic potential for treatment of gastrointesti nal diseases associated with Helicobacter pylori infection.