SEQUENTIAL TREATMENT OF RECURRENT MESENTERIC DESMOID TUMOR

BACKGROUND. The optimal management of inoperable desmoid tumors is sti ll unclear. We report a 26 year-old female patient with familial adeno matous polyposis suffering from a recurrent inoperable intraabdominal desmoid tumor and its sequential treatment. METHODS. Treatment strateg ies included low-dose tamoxifen (30 mg orally per day), high-dose tamo xifen (90 mg orally per day), and a subsequent combination of gosereli n acetate (3.6 mg subcutaneously once every four weeks) plus low-dose tamoxifen, medroxyprogesterone acetate (1000 mg orally per day) and in terferon gamma (3 Mio IU subcutaneously 3 times a week). RESULTS. The combination of goserelin acetate and low-dose tamoxifen resulted in a decrease in tumor size and a complete relief of symptoms for 17 months . Thereafter the tumor progressed and again growth was stopped with in terferon gamma therapy for another 6 months. All other treatment modal ities had no effect. CONCLUSIONS. This study demonstrates long-term re gression of a desmoid tumor with combined endocrine therapy using gose relin acetate plus tamoxifen. Tumor progression after 17 months was ag ain stopped by a combination of interferon-gamma and goserelin acetate . (C) 1996 American Cancer Society.