A SYNTHETIC ROUTE TO THE ALKALOIDS OF THE ERVATAMINE GROUP - FIRST TOTAL SYNTHESIS OF (+ -)-6-OXO-16-EPISILICINE/

Citation
Ml. Bennasar et al., A SYNTHETIC ROUTE TO THE ALKALOIDS OF THE ERVATAMINE GROUP - FIRST TOTAL SYNTHESIS OF (+ -)-6-OXO-16-EPISILICINE/, Chemical communications, (24), 1996, pp. 2755-2756
Citations number
16
Categorie Soggetti
Chemistry
Journal title
ISSN journal
13597345
Issue
24
Year of publication
1996
Pages
2755 - 2756
Database
ISI
SICI code
1359-7345(1996):24<2755:ASRTTA>2.0.ZU;2-I
Abstract
A general route to silicine-methuenine alkaloids, exemplified by. the synthesis of 6-oxo-16-episilicine, involving the nucleophilic addition of an acetylindole enolate to the pyridinium salt 2, methoxycarbonyla tion of the resulting 1,4-dihydropyridine, controlled catalytic hydrog enation, cyclization on the indole 3-position and further functional g roup manipulations, is reported.