SYNTHESIS OF CARBOCYCLIC NAD(-RIBOSYL CYCLASE() CONTAINING A METHYLENEBISPHOSPHONATE LINKAGE FOR THE INVESTIGATION OF ADP)

Authors
HUTCHINSON EJ TAYLOR BF BLACKBURN GM
Citation
Ej. Hutchinson et al., SYNTHESIS OF CARBOCYCLIC NAD(-RIBOSYL CYCLASE() CONTAINING A METHYLENEBISPHOSPHONATE LINKAGE FOR THE INVESTIGATION OF ADP), Chemical communications, (24), 1996, pp. 2765-2766
Citations number
25
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
24
Year of publication
1996
Pages
2765 - 2766
Database
ISI
SICI code
1359-7345(1996):24<2765:SOCNCC>2.0.ZU;2-G
Abstract
A stereospecific synthesis of carbocyclic NAD(+) incorporating a methy lenebisphosphonatelinkage in place of the natural pyrophosphate gives an analogue 4 of the natural coenzyme NAD(+) 3a designed to act as an inhibitor of ADP-ribosyl cyclase and to resist non-specific phosphatas e degradation.