ATYPICAL PRESENTATION OF 4-AMINOPYRIDINE OVERDOSE

4-Aminopyridine (4-AP) is an investigational drug for the treatment of neurologic disorders including multiple sclerosis (MS). Until recentl y, relatively little was known about 4-AP toxicity in overdose; the on ly recorded cases involved neurologic symptoms ranging from mild paras thesias to tonic-clonic seizures. We report a case of accidental 4-AP overdose that resulted in continuous, dystonic, choreoathetoid-type mo vements that responded to treatment with standard anticonvulsant dosag es of benzodiazepines.