Ft. Hufert et al., LIVER-FAILURE DUE TO DISSEMINATED HSV-1 INFECTION IN A NEWBORN TWIN, Scandinavian journal of infectious diseases, 27(6), 1995, pp. 627-629
Most cases of neonatal herpes simplex virus (HSV) infection result fro
m contact with maternal genital tract secretions and are caused by inf
ections with HSV type 2. We report on a fatal HSV-1 infection in a new
born twin presenting with liver failure, The infection was acquired by
single contact with an aunt. The route of transmission was proven by
PCR followed by restriction endonuclease fingerprinting and DNA sequen
cing, This report demonstrates that liver failure may be an early and
single symptom in life-threatening neonatal HSV-1 infection.