M. Campanello et al., BONE-MINERAL AND RELATED BIOCHEMICAL VARIABLES IN PATIENTS WITH KOCK ILEAL RESERVOIR OR BRICKER CONDUIT FOR URINARY-DIVERSION, The Journal of urology, 155(4), 1996, pp. 1209-1213
Purpose: Bone mineral content was studied with single photon absorptio
metry and dual energy x-ray absorptiometry, and the various biochemica
l parameters related to bone metabolism in patients with Kock reservoi
rs or Bricker conduits for urinary diversion. Materials and Methods: W
e examined 34 patients with Kock ileal reservoirs to the skin (29) or
urethra (5) and 14 with Bricker conduits 2 to 17 years after urinary d
iversion. Bone mineral density was measured in the radius with single
photon absorptiometry, and in the femur, lumbar spine and whole body w
ith dual x-ray absorptiometry. Serum concentrations of 25-hydroxyvitam
in D, 1,25-dihydroxyvitamin D, osteocalcin, parathyroid hormone, bone
specific alkaline phosphatase and ionized calcium were determined. Art
erial blood gasses were analyzed. Results: The mean values for bone mi
neral density did not differ from age-matched controls in either group
and no signs of decrease were observed with followup. Vitamin D serum
concentration values remained within normal limits in all patients. M
ost patients had normal blood gas values. Mean values for osteocalcin,
parathyroid hormone, bone specific alkaline phosphatase and ionized c
alcium also were within normal limits, although a few patients had ele
vated osteocalcin values indicating increased bone turnover. Conclusio
ns: Urinary diversion with a Kock reservoir or Bricker conduit did not
cause bone demineralization or significant changes in different marke
rs of bone metabolism in patients examined 2 to 17 years after urinary
diversion.