URODYNAMIC AND CLINICAL EFFECTS OF TERAZOSIN THERAPY IN PATIENTS WITHSYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA

Purpose: We evaluated the urodynamic and clinical effects of terazosin in patients with symptomatic benign prostatic hyperplasia (BPH). Mate rials and Methods: A total of 45 patients who participated in a multic enter trial was evaluated with urodynamic pressure-flow studies before and after 26 weeks of treatment. Results: Maximum flow rate and sympt om score improved significantly in 22 patients with and 11 without bla dder outlet obstruction who completed 26 weeks of treatment. In patien ts with bladder outlet obstruction the condition was significantly red uced and in patients without obstruction, significant urodynamic chang es could not be detected. Conclusions: Terazosin treatment results in symptomatic relief and improved urinary flow in patients with and with out bladder outlet obstruction, and in significant improvement in pati ents with urodynamically proved obstruction.