PROTECTIVE EFFECT OF TADENAN ON BLADDER FUNCTION SECONDARY TO PARTIALOUTLET OBSTRUCTION

Purpose: Tadenan (DEBAT, Paris, France) is a pharmaceutical agent used in the treatment of benign prostatic hyperplasia (BPH). The specific aim of this study was to determine if pretreatment of rabbits with Tad enan reduced either the hypertrophic response of the bladder to partia l outlet obstruction or the accompanying contractile dysfunctions. Mat erials and Methods: Twenty-five male New Zealand rabbits (3 to 5 kg.) were separated into 5 groups of 5 rabbits each. Each rabbit in groups 1, 2, and 3 received Tadenan orally at 1, 10 and 100 mg./kg./day for 3 weeks. Group 4 received vehicle only (peanut oil); Group 5 were contr ols. The bladders were evaluated (in vitro studies) after 2 weeks of o bstruction. Results: 1) Tadenan did not reduce the effect of partial o utlet obstruction on bladder mass. 2) Tadenan pretreatment resulted in a significant protective effect on the contractile responses to field stimulation, bethanechol and KCl. Conclusions: These results clearly demonstrate that Tadenan pretreatment protected the bladder from the c ontractile dysfunctions induced by partial outlet obstruction.