BRAIN SPECT OF CREUTZFELDT-JAKOB-DISEASE

SPECT imaging with I-123 IMP or Tc-99m HMPAO was performed in two pati ents with Creutzfeldt-Jakob disease to evaluate abnormalities in brain perfusion, In the first patient, there was decreased perfusion of the left frontal, parietal, and temporal lobes, CT and MRI were negative, In the second patient, there was patchy perfusion and slightly decrea sed perfusion of the right hemisphere, MRI revealed slight brain atrop hy and bilateral high intensity areas in the basal ganglia on T2 weigh ted Images, Subsequent SPECT imaging revealed severely decreased perfu sion of the entire brain, Subsequent MRI demonstrated severe brain atr ophy.