DETECTION OF MALIGNANT-TUMORS USING TC-99M LABELED FAB' FRAGMENTS FROM A MONOCLONAL-ANTIBODY WITH SPECIFICITY FOR D-DIMER OF CROSS-LINKED FIBRIN

The authors present the case studies of two patients whose malignant t umors were detected with a Tc-99m labeled antifibrin monoclonal antibo dy (DD-3B6/22), which is specific for cross-linked fibrin, The first c ase was a malignant fibrous histiocytoma involving the proximal aspect of the left thigh, whereas in the second case, the patient was receiv ing treatment for a squamous cell carcinoma of the right mainstem bron chus, The results highlight the potential of this anti-D-dimer radioph armaceutical for noninvasive detection of malignant tumors.