REVERSIBLE CEREBRAL PERFUSION ABNORMALITIES ASSOCIATED WITH CYCLOSPORINE THERAPY IN ORTHOTOPIC LIVER-TRANSPLANTATION

A 60-yr-old woman experienced several episodes of generalized seizures following 2 wk of immunosuppressive therapy with cyclosporine for ort hotopic liver transplantation. CT showed low density in the white matt er of the parieto-occipital lobes. A Tc-99m-HMPAO brain SPECT showed d iminished perfusion in the parieto-occipital cortex bilaterally, Altho ugh the cyclosporine was discontinued, the patient's neurologic status initially worsened and then improved over the next several days, Repe at perfusion brain SPECT showed resolution of most of the perfusion ab normalities, while repeat CT showed persistent white matter changes in the parieto-occipital lobes. We report the presence of reversible cor tical perfusion abnormalities in conjunction with cyclosporine therapy , The findings suggest that perfusion brain SPECT may be a sensitive m onitor of cyclosporine-induced neurotoxicity.