Although the incidence of mediastinal wound infection in patients unde
rgoing median sternotomy for cardiopulmonary bypass is less than 1%, i
ts associated morbidity, mortality, and ''cost'' remain unacceptably h
igh. There is considerable lack of consensus regarding the ideal opera
tive treatment of complicated median sternotomy wounds. The aim of thi
s article is to review the current preventive, diagnostic, and therape
utic techniques offered to patients with mediastinitis. We also propos
e a new classification for postoperative mediastinitis. Data from the
English-language literature suggest that the type of mediastinitis and
direct assessment of the mediastinum under general anesthesia are the
main determinants of the nature of subsequent operative treatment. Wo
und debridement and removal of foreign materials are essential steps o
f whatever procedures are applied. Closed mediastinal irrigation can b
e successful in type I mediastinitis, whereas major reconstructive ope
ration is probably the treatment of choice for patients with mediastin
itis types II to V. Refinement of the current diagnostic tools and fur
ther evaluation of the benefits of primary sternal fixation in combina
tion with a reconstructive procedure in mediastinitis types I to III c
ould improve the outcome of this dreaded complication.