ERGOLINE DERIVATES AS A PROBE FOR FEATURING THE 5-HT1A RECEPTOR PHARMACOPHORE

A 5-HT1A pharmacophore has been obtained employing a set of rigid temp lates encompassing the 5-HT structure. The use of rigid templates allo wed us to overcome the discrepancy found when flexible structures wher e the energy of the active conformers are sometimes higher than the gl obal minimum energy are used. On the basis of the results herein repor ted the three-dimensional requirements necessary for the binding inter action have been defined within this set of molecules. In this study f orbidden zones of the receptor have been characterised. The pharmacoph ore model derived places some agonist/antagonist pharmacophore models appeared in the literature in question.