HIGHLY CHEMOSELECTIVE AND STEREOSELECTIVE FE-CATALYZED ALKENYLATION OF ORGANOMANGANESE REAGENTS

Organomanganese chlorides react with alkenyl iodides, bromides and chl orides in the presence of 3% Fe(acac)(3). The reaction takes place und er very mild conditions (THF-NMP, rt, 1h) to afford the substituted ol efin in excellent yields with a high stereo- and chemoselectivity. Thu s an unprotected keto alkenyl chloride selectively gives the correspon ding keto olefin. From a preparative point of view, this procedure is the first real alternative to the Pd- and Ni-cross coupling reaction u sed until now.