S. Shawponter et al., ACYL CARBAMATE DIRECTING GROUPS IN NUCLEOSIDE SYNTHESIS - APPLICATIONS IN THE SYNTHESIS OF 2'-DEOXY-5-ETHYL-4'-THIOURIDINE, Tetrahedron letters, 37(11), 1996, pp. 1867-1870
The use of the 3-O-(N-acyl)carbamoyl directing groups in the synthesis
of the potent anti-Herpes virus agent 2'-deoxy-5-ethyl-4'-thio-D-urid
ine is described. This includes details of experiments to optimise the
carbamate substitution and a multi-gram exemplification of the key st
eps.