ACYL CARBAMATE DIRECTING GROUPS IN NUCLEOSIDE SYNTHESIS - APPLICATIONS IN THE SYNTHESIS OF 2'-DEOXY-5-ETHYL-4'-THIOURIDINE

Authors
SHAWPONTER S MILLS G ROBERTSON M BOSTWICK RD HARDY GW YOUNG RJ
Citation
S. Shawponter et al., ACYL CARBAMATE DIRECTING GROUPS IN NUCLEOSIDE SYNTHESIS - APPLICATIONS IN THE SYNTHESIS OF 2'-DEOXY-5-ETHYL-4'-THIOURIDINE, Tetrahedron letters, 37(11), 1996, pp. 1867-1870
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
11
Year of publication
1996
Pages
1867 - 1870
Database
ISI
SICI code
0040-4039(1996)37:11<1867:ACDGIN>2.0.ZU;2-K
Abstract
The use of the 3-O-(N-acyl)carbamoyl directing groups in the synthesis of the potent anti-Herpes virus agent 2'-deoxy-5-ethyl-4'-thio-D-urid ine is described. This includes details of experiments to optimise the carbamate substitution and a multi-gram exemplification of the key st eps.