This issue of Protein Profile deals with the rapidly growing superfami
ly of nuclear receptors. It was difficult to fix a deadline for the co
mpilation of data, as continuously novel and exciting studies were pub
lished while this manuscript was in preparation. Consequently, the bul
k of citations considers papers published until October 1994. However,
we also incorporated, on a nonsystematic basis, several studies that
we felt should be mentioned in this issue, as they may open new avenue
s for future research (e.g. work on nuclear receptor-binding proteins
and 3D studies). We apologize to all our colleagues whose work was not
, or inadequately, considered in this issue. Please do not hesitate to
contact us if you feel that your reference(s) should be discussed or
added under a certain topic. If you provide us with the corresponding
reprints, we may incorporate your suggestions in the forthcoming Nucle
ar Receptor issue of Protein Profile. It has not been possible to trea
t all aspects of Nuclear Receptors in this issue. In fact, we concentr
ate mainly on what we have learned about nuclear receptor structure an
d function in the 'post-cloning' era. Therefore, with the exception of
some examples to illustrate a certain aspect of nuclear receptor acti
on, we will not discuss in this issue ligand chemistry, pharmacology,
or endocrine therapies.