TRANSCRIPTION FACTORS .3. NUCLEAR RECEPTORS

This issue of Protein Profile deals with the rapidly growing superfami ly of nuclear receptors. It was difficult to fix a deadline for the co mpilation of data, as continuously novel and exciting studies were pub lished while this manuscript was in preparation. Consequently, the bul k of citations considers papers published until October 1994. However, we also incorporated, on a nonsystematic basis, several studies that we felt should be mentioned in this issue, as they may open new avenue s for future research (e.g. work on nuclear receptor-binding proteins and 3D studies). We apologize to all our colleagues whose work was not , or inadequately, considered in this issue. Please do not hesitate to contact us if you feel that your reference(s) should be discussed or added under a certain topic. If you provide us with the corresponding reprints, we may incorporate your suggestions in the forthcoming Nucle ar Receptor issue of Protein Profile. It has not been possible to trea t all aspects of Nuclear Receptors in this issue. In fact, we concentr ate mainly on what we have learned about nuclear receptor structure an d function in the 'post-cloning' era. Therefore, with the exception of some examples to illustrate a certain aspect of nuclear receptor acti on, we will not discuss in this issue ligand chemistry, pharmacology, or endocrine therapies.