M. Cigolini et al., PLASMA FACTOR-VII AND ITS RELATION TO ADIPOSE-TISSUE FATTY-ACIDS AND OTHER ATHEROGENIC RISK-FACTORS IN HEALTHY-MEN, European journal of clinical investigation, 26(3), 1996, pp. 247-253
Citations number
42
Categorie Soggetti
Medicine, Research & Experimental","Medicine, General & Internal
In this study the authors examined the relationships of plasma factor
VII (F-VII) to adipose tissue fatty acid composition, as an objective
index of the habitual dietary fat intake, as well as to a number of ot
her atherogenic risk factors in 60 healthy male volunteers (aged 38 ye
ars). Significant positive correlations were found between plasma F-VI
I [measured as antigen (F-VIIAg) and coagulant activity, using bovine
thromboplastin (F-VIIbt)] and body mass index (BMI), waist-thigh girth
ratio (WTR), cigarette smoking and plasma triglyceride concentration.
After adjustment for BMI, only plasma triglycerides remained positive
ly correlated with F-VII (r=0.27, P=0.03, and r=0.29, P<0.01, for F-VI
Ibt and F-VIIAg respectively). A significant positive relation was fou
nd between F-VII and the total proportion of fatty acid as monounsatur
ated fatty acid (r=0.26, P < 0.05, for F-VIIAg), whereas inverse relat
ions were found between F-VII, the total proportion of fatty acid as p
olyunsaturated fatty acid (r=-0.26 and r=-0.25, P < 0.05, for F-VIIbt
and F-VIIAg respectively), polyunsaturated-saturated fat ratio (r=-0.2
5, P < 0.05, for F-VIIbt) and, more significantly, between F-VII and a
dipose-tissue alpha-linolenic acid (r=-0.29, P < 0.01, for F-VIIbt and
r=-0.49, P < 0.001, for F-VLIAg). All these correlations remained sig
nificant after matching for BMI. In a multiple linear regression analy
sis, only adipose tissue alpha-linolenic acid was a negative and indep
endent predictor of F-VIIAg (P=0.004) and, at borderline significance,
of F-VIIbt (P=0.061) when allowance was made for BMI, WTR, smoking an
d plasma triglycerides. In conclusion, this study shows significant re
lations between F-VII and adipose tissue fatty acid composition in hea
lthy male individuals; it supports the possibility that adipose tissue
polyunsaturated fatty acids, derived from dietary intake, play a role
in the relation between F-VII and coronary heart disease (CHD), thus
suggesting that high dietary polyunsaturated fatty acid intake (especi
ally alpha-linolenic acid) may reduce the risk for CHD by an improveme
nt of a number of risk factors, including a lowering of plasma F-VII (
both activity and antigen).