ROLE OF SEROTONIN(3) RECEPTORS IN PROLACTIN-RELEASE INDUCED BY ELECTROCONVULSIVE-THERAPY - A STUDY WITH ONDANSETRON

Authors
YATHAM LN ZIS AP LAM RW SRISURAPANONT M MCGARVEY K AGBAYEWA O
Citation
Ln. Yatham et al., ROLE OF SEROTONIN(3) RECEPTORS IN PROLACTIN-RELEASE INDUCED BY ELECTROCONVULSIVE-THERAPY - A STUDY WITH ONDANSETRON, Psychiatry research, 60(1), 1996, pp. 33-39
Citations number
27
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Psychiatry research → ACNP
ISSN journal
01651781
Volume
60
Issue
1
Year of publication
1996
Pages
33 - 39
Database
ISI
SICI code
0165-1781(1996)60:1<33:ROSRIP>2.0.ZU;2-9
Abstract
The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressi ve patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ond ansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to atten uate ECT-induced PRL release suggested that serotonin, receptors are n ot involved in mediating this response.