Ll. Davis et al., GROWTH-HORMONE RESPONSE TO BACLOFEN - A COMPARISON OF 10-MG AND 20-MGDOSES IN HEALTHY-MEN, Psychiatry research, 60(1), 1996, pp. 41-47
Growth hormone (GH) response and baclofen levels were measured in seve
n healthy adult men following a 10-mg and a 20-mg dose of oral baclofe
n (gamma-aminobutyric acid(B) agonist) to determine the preferred dose
in baclofen challenge studies. Multivariate analysis of variance (ANO
VA) with repeated measures revealed no differences between the doses,
However, when a univariate ANOVA with repeated measures was performed
for each dose, the 10-mg dose showed no significant GH response over t
ime, whereas the 20-mg dose showed a significant GH response over time
. The average Delta GH (change in GH from baseline) was 7.84 ng/ml (SD
= 10.17) for the 10-mg dose and 3.34 ng/ml (SD = 3.64) for the 20-mg
dose. The variability in the Delta GH response to the 10-mg dose was s
ignificantly greater than the response to the 20-mg dose of baclofen.
This variance in GH response was not explained by the differences in s
erum baclofen levels. Thus, a 20-mg baclofen dose appears to be prefer
able to a 10 mg-dose in baclofen challenge studies.