Js. Minana et al., HEPATITIS-B VACCINE IMMUNORESPONSIVENESS IN ADOLESCENTS - A REVACCINATION PROPOSAL AFTER PRIMARY VACCINATION, Vaccine, 14(2), 1996, pp. 103-106
Hepatitis B recombinant vaccine immunoresponsiveness was studied in 42
7 preadolescents vaccinated with a 0, 1 and 6 months vaccination sched
ule. AntiHBs postvaccination titres (measured one month after the last
dose) were related to the following variables: sex, weight, height, a
nd Quetelet index. The antiHBs postvaccination titres were used to pre
dict the length of protection induced by the vaccine. AN preadolescent
s developed antiHBs titres 10 IU l(-1) and no statistically significan
t differences could be found between sexes. The relation study between
antiHBs postvaccination levels and Quetelet index showed a statistica
lly significant inverse correlation According to the antiHBs postvacci
nation titres, the central 50% of the sample distribution would be pro
tected during a period between 7.5 and 10.5 years. In pre-teenagers, t
he hepatitis B recombinant vaccine has proven to be highly immunogenic
, obesity is a predictor of poor immunoresponse and this response is n
ot influenced by sex. According to our. results, we would propose the
administration of a single booster dose 10 years after primary vaccina
tion and thus protect these subjects during the period of greatest ris
k.