2 DIFFERENT DOSAGES OF YEAST-DERIVED RECOMBINANT HEPATITIS-B VACCINES- A COMPARISON OF IMMUNOGENICITY

The efficacy of a 10 or 20 mu g antigen load of HE recombinant vaccine s is still being debated A comparison of anti-HBs titres in two groups of healthy subjects vaccinated by the same schedule (0, 1 and 6 month s) employing recombinant HE vaccines with different antigen loads, 20 mu g (group A, 251 subjects) and 10 mu g (group B, 256 subjects) was c arried out. A seroprotection rate of 99.6 and 99.2% was observed for g roup A and group B, respectively, at the end of primary immunization. No statistically significant difference in seroprotection rate was obs erved. Group A showed significantly higher GMTs than group B for all a ge groups and for both sexes except for males above 25 years. The diff erence was more marked for younger age groups and for the female sex. These data support the higher immunogenicity of vaccine with 20 mu g a ntigen load as compared to vaccines with 10 mu g antigen load.