CHARACTERIZATION OF 2 ISOLATES OF TRYPANOSOMA-CRUZI OBTAINED FROM THEPATIENT BERENICE, THE FIRST HUMAN CASE OF CHAGAS-DISEASE DESCRIBED BYCHAGAS,CARLOS IN 1909

Authors
DELANA M CHIARI CA CHIARI E MOREL CM GONCALVES AM ROMANHA AJ
Citation
M. Delana et al., CHARACTERIZATION OF 2 ISOLATES OF TRYPANOSOMA-CRUZI OBTAINED FROM THEPATIENT BERENICE, THE FIRST HUMAN CASE OF CHAGAS-DISEASE DESCRIBED BYCHAGAS,CARLOS IN 1909, Parasitology research, 82(3), 1996, pp. 257-260
Citations number
24
Categorie Soggetti
Parasitiology
Journal title
Parasitology research → ACNP
ISSN journal
09320113
Volume
82
Issue
3
Year of publication
1996
Pages
257 - 260
Database
ISI
SICI code
0932-0113(1996)82:3<257:CO2IOT>2.0.ZU;2-T
Abstract
Two isolates of Trypanosoma cruzi were obtained from the patient Beren ice, the first human case of Chagas' disease (Chagas 1909), when she w as 55 and 71 years old, respectively. The isolates were characterized on the basis of their epimastigote-trypomastigote differentiation in l iquid media and of the electrophoretic pattern of EcoR1 digestion prod ucts of kinetoplast DNA (k-DNA) minicircles (schizodeme) and isoenzyme patterns (zymodeme). Clear differences were found between the isolate s, suggesting the occurrence of a heterogeneous population of T. cruzi in the infection of this patient.