EFFECTS OF OIL ADJUVANT ON SYSTEMIC RESPONSE TO ESCHERICHIA-COLI LIPOPOLYSACCHARIDE IN SWINE

Authors
NORIMATSU M OGIKUBO Y KOJIMA A TAKAHASHI T WATANABE G TAYA K SASAMOTO S TAMURA Y
Citation
M. Norimatsu et al., EFFECTS OF OIL ADJUVANT ON SYSTEMIC RESPONSE TO ESCHERICHIA-COLI LIPOPOLYSACCHARIDE IN SWINE, Journal of veterinary medical science, 57(6), 1995, pp. 1089-1091
Citations number
11
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
57
Issue
6
Year of publication
1995
Pages
1089 - 1091
Database
ISI
SICI code
0916-7250(1995)57:6<1089:EOOAOS>2.0.ZU;2-P
Abstract
Intramuscular injection of 0.1 mg/kg of Escherichia coli lipopolysacch aride (LPS) mixed with Freund's complete adjuvant (LPS+FCA) in piglets mitigated the leukopenia and TNF-alpha and cortisol levels in the ser um compared with that of LPS suspended in LPS-free saline. The endotox in level in the serum of the LPS + FCA was remarkably reduced. These r esults suggest that the addition of oil adjuvant mitigate the systemic toxicity of LPS.