THE FELINE HERPESVIRUS TYPE-1 ICP4 DOWN-REGULATES FELINE IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT (LTR)-DIRECTED GENE-EXPRESSION VIA THEC EBP SITE IN THE LTR/

Authors
KAWAGUCHI Y MAEDA K PECORARO MR INOSHIMA Y JANG HK KOHMOTO M IWATSUKI K IKEDA Y SHIMOJIMA M TOHYA Y KAI C MIKAMI T
Citation
Y. Kawaguchi et al., THE FELINE HERPESVIRUS TYPE-1 ICP4 DOWN-REGULATES FELINE IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT (LTR)-DIRECTED GENE-EXPRESSION VIA THEC EBP SITE IN THE LTR/, Journal of veterinary medical science, 57(6), 1995, pp. 1129-1131
Citations number
18
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
57
Issue
6
Year of publication
1995
Pages
1129 - 1131
Database
ISI
SICI code
0916-7250(1995)57:6<1129:TFHTID>2.0.ZU;2-I
Abstract
We investigated effects of feline herpesvirus type 1 (FHV-1) ICP4 on f eline immunodeficiency virus (FIV) long terminal repeat (LTR)-directed gene expression by transient transfection assay in Crandell feline ki dney cells. We demonstrated that FHV-1 ICP4 significantly stimulates t he FIV LTR after introduction of site-specific mutation of the C/EBP s ite in the LTR, and the C/EBP site is sufficient to confer inhibitory effects by FHV-1 ICP4 on a heterologous promoter. These results indica te that FHV-1 ICP4 possesses both ability to transactivate FIV LTR-dir ected gene expression and to down-regulate the FIV LTR via the C/EBP s ite.